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RET»ùÒòÒì³£»£»£»£»£» £»£»£»î»¯Ö÷Òª°üÀ¨»ùÒòÈںϡ¢µãÍ»±ä¡¢¹ý±í´ïÈýÖÖ»úÖÆ£¬£¬£¬£¬£¬£¬¿Éµ¼Ö¶àÖÖ°©Ö¢¡£¡£¡£¡£¡£RET»ùÒòµãÍ»±äÔÚ¼××´ÏÙËèÑù°©(MTC)Öеı¬·¢ÂÊԼΪ60%-90%£¬£¬£¬£¬£¬£¬ÆäÖÐ×î³£¼ûµÄÍ»±äλµãÊÇM918T¡£¡£¡£¡£¡£RET»ùÒòÈÚºÏÔÚ¼××´ÏÙÈéÍ·×´°©(PTC)Öб¬·¢ÂÊΪ10%-20%;ÔÚ·ÇСϸ°û·ÎÏÙ°©»¼ÕßÖеı¬·¢ÂÊԼΪ1-2%£¬£¬£¬£¬£¬£¬ÆäÖÐÒÔKIF5B-RET×îΪ¶à¼û¡£¡£¡£¡£¡£

 

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ÏÖÔÚ¹ØÓÚRET»ùÒò¸Ä±äÀàÖ×ÁöµÄÖÎÁƼƻ®Ö÷ÒªÊÇʹÓöà°Ðµã¼¤Ã¸ÒÖÖÆ¼ÁÀàÒ©Î£¬£¬£¬£¬£¬ºÃ±È¿¨²©ÌæÄá¡¢·²µÂËûÄᣬ£¬£¬£¬£¬£¬ÕâЩҩÎï²»µ«ÒÖÖÆRETÂѰ×£¬£¬£¬£¬£¬£¬Í¬Ê±»áÒÖÖÆVEGFR¡¢EGFRµÈÆäËûÂѰס£¡£¡£¡£¡£2020Äê5ÔÂ8ÈÕ£¬£¬£¬£¬£¬£¬FDA¼ÓËÙÅú×¼ÁËÈ«ÇòÊ׸ö¸ßÑ¡ÔñÐÔRET¼¤Ã¸ÒÖÖÆ¼ÁLOXO-292 (selpercatinib £¬£¬£¬£¬£¬£¬ÀñÀ´)£¬£¬£¬£¬£¬£¬ºÍÆäËû°ÐÏòÒ©Ò»Ñù£¬£¬£¬£¬£¬£¬LOXO-292Ò²»áÄÍÒ©¡£¡£¡£¡£¡£ÁÙ´²Ç°Ñо¿ÏÔʾ£¬£¬£¬£¬£¬£¬RETÈÚºÏNSCLC»¼ÕßʹÓÃLOXO-292ÖÎÁƺ󣬣¬£¬£¬£¬£¬¿É±¬·¢G810R/S/CÈܼÁÇ°ÑØÍ»±ä£¬£¬£¬£¬£¬£¬µ¼ÖÂLOXO-292ÄÍÒ©¡£¡£¡£¡£¡£

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¡¾1¡¿Advances in Targeting RET-Dependent Cancers. Cancer Discov. ,2020,10:498¨C505.

¡¾2¡¿RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies. J.Thorac. Oncol.;2020, 15:541-549.

 

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